High-throughput fixed target SFX for pharmaceutical screening at the European XFEL

Serial femtosecond crystallography (SFX) is unique to XFELs. Collect damage-free protein structures. Femtosecond X-ray pulses are faster than damage processes in crystals. Room temperature data collection is important for ligand binding. Temperature affects ligand-binding to protein molecules Room temperature structures better represent in vivo binding behaviour. Fixed target sample delivery. Liquid jets require large volumes of sample, wasted between pulses. Fixed targets are far more sample efficient. X-ray based drug design platform (XDD) project. Center for Free-Electron Laser Science (DESY), European XFEL, University of Hamburg, University of Gothenburg, MAX IV Laboratory. Developing a pipeline for high-throughput pharmaceutical compound screening and structure-based drug design.