Record Details

Extension of Sase Bandwidth Up to 2% as a Way to Increase Number of Indexed Images for Protein Structure Determination by Femtosecond X-ray Nanocrystallography at the European XFEL
EuXFEL staff
Author group:
Simulation of Photon Fields
Experiments at the LCLS confirmed the feasibility of femtosecond nanocrystallography for protein structure determination at near-atomic resolution. These experiments rely on X-ray SASE pulses with a fewmicroradians angular spread, and about 0.2 % bandwidth. By indexing individual patterns and then summing all counts in all partial reflections for each index it is possible to extract the square modulus of the structurefactor. The number of indexed images and the SASE bandwidth are linked, as an increasing number of Bragg spots per individual image requires an increasing spectral bandwidth. This calls for a few percent SASEbandwidth. Based on start-to-end simulations of the European XFEL baseline, we demonstrate that it is possible to achieve up to a 10-fold increase of the electron energy chirp by strongly compressing a 0.25 nCelectron bunch. This allows for data collection with a 2 % SASE bandwidth, a few mJ radiation pulse energy and a few fs-pulse duration, which would increase the efficiency of protein determination at the European XFEL. We prove this concept with simulations of photosystem-I nanocrystals, with a size of about 300 nm.
Report number:
1892 - WEPSO63
Conference information:
35th International Free-Electron Laser Conference, FEL 2013, New York, 2013-08-26 - 2013-08-30, USA
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 Record created 2016-10-11, last modified 2019-01-30

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