Serial femtosecond crystallography (SFX) is a technique unique to XFELs. Damage-free protein structures. Femtosecond X-ray pulses faster than damage processes within crystals. Room temperature data collection important for ligand binding. Temperature affects ligand binding to protein molecules. Room temperature structures better represent in vivo binding behavior. Fixed target sample delivery. Liquid jets require large volumes of sample, wastage between pulses. Fixed targets are far more sample efficient. X-ray based drug design platform (XDD) project (DESY, European XFEL, University of Hamburg, University of Gothenburg, MAX IV Laboratory). Develop a pipeline for high-throughput pharmaceutical compound screening and structure-based drug design.