The DSSC mega-pixel X-ray imager is being developed for experiments at the European XFEL for low energies between 0.5 keV and 6 keV. The smallest unit comprises the electronics for the operation and readout of 512-by-128 pixels. The current version is based on miniaturized silicon-drift detector (mini-SDD) cells. A future active sensor type based on DEPFETs is currently available in a smaller format of 64-by-64 pixels and uses the same electronics. For both detector types, the readout ASIC comprises a filter for analog signal processing, an 8-bit ADC for digitization, and a memory to store up to 800 images on pixel level. Due to versatility of the control system, both detector types can be flexibly operated at different types of X-ray sources (radioactive, synchrotron, FEL). We present the operation and results of the small-format DEPFET module and the first full-format mini-SDD module at a synchrotron beam line of Petra III.