The European X-ray Free Electron Laser is a high-intensity X-ray light source currently being constructed in the Hamburg region that will provide spatially coherent X-rays in the energy range between 0.25 keV-25 keV. The LPD, DSSC and AGIPD detectors are being developed to provide megapixel imaging capabilities with a dynamic range spanning from single photon sensitivity to 10⁵ photons per pixel. Calibration of these detectors is challenging as a large set of calibration parameters (up to 10⁹) exist. To provide a drop-in replacement for measured megapixel detector data, the X-ray Camera Simulation Toolkit (X-CSIT) has been developed. Based on X-CSIT, a X-ray detector simulation pipeline (XDSP) has been assembled to simulate a realistic detector response at a given experimental configuration. Validation of XDSPs have been performed and an XDSP for the SPB/SFX imaging experiment based on calibration data of an AGIPD module has been implemented and integrated into the experiment's start-to-end simulation framework simS2E.