The DSSC (DEPFET Sensor with Signal Compression) collaboration develops a hybrid pixelated X-Ray photon detector with 4.5 MHz frame rate and immediate amplitude digitization for experiments at the European XFEL. We present the first full format 14.9×14 mm 2 F1 pixel readout ASIC for the DSSC detector. The readout architecture is specially adapted to the burst structure of the XFEL (bursts of 2880 pulses spaced by down to 220 ns at a rate of 10 Hz) by in-pixel digitization and digital hit data storage and data transfer during the burst gaps. The readout ASIC contains 64×64 pixels of 229×204 μm 2 size and includes per pixel two low noise front-end versions for DEPFET and silicon drift detectors (SDD), a single-slope 8-bit ADC and local memory. Measurements using the F1 ASIC and a matching mini-SDD sensor matrix are shown.