Scientific instruments at the European X-Ray Free Electron Laser Facility (EuXFEL) comprises of a large variety of equipment, ranging from controllers, motors and encoders to valves. It is a false assumption that once a specific equipment had been procured and integrated, that no further attention is required. Reality is much more complex and incorporates various stages across the entire equipment life-cycle. This starts from the initial selection, standardization of the equipment, procurement, integration, tracking, spare part management, maintenance, documentation of interventions and repair, replacement and lastly, decommissioning. All aspects of such a life-cycle management are crucial in order to ensure safe and reliable operation across the life time of the equipment, whether it be five years, twenty years, or longer. At EuXFEL, many aspects of the described life-cycle management are already carried out with dedicated tools. However some aspects rely on manual work, which requires significant effort and discipline. This contribution aims to provide an overview of the requirements, and the ongoing efforts to develop and establish a complete life-cycle management at the EuXFEL.