Record Details

Title:
Gold-Catalyzed C-S Aryl-Group Transfer in Zinc Finger Proteins
Affiliation(s):
EuXFEL staff, Other
Author group:
Instrument FXE
Keyword(s):
Topic:
Scientific area:
Abstract:
Reaction of the Au–C N chelate $[Au(bnpy)Cl_{2}]$ with the full‐length zinc finger (ZnF; $ZnCys_{3}His$) of HIV nucleocapsid protein NCp7 results in C–S aryl transfer from the $Au^{III}$ organometallic species to a cysteine of the ZnF. The reaction is general and occurs even for finger 3 of the transcription factor Sp1, containing a $ZnCys_{2}His_{2}$ coordination sphere. This reaction is the first demonstration of group transfer from a coordination compound to biologically important zinc fingers, and is especially noteworthy for the $ZnCys_{2}His_{2}$ transcription factors. The work expands the corpus of organometallic species which can efficiently modify biomolecules through C‐atom transfer. The electronic features of the gold compound leading to this unexpected reaction were explored by X‐ray absorption spectroscopy.
Imprint:
Wiley, 2018
Journal Information:
Angewandte Chemie International Edition, 57 (30), 9305-9309 (2018)
Related external records:
Language(s):
English


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 Record created 2019-02-27, last modified 2019-02-27

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