Record Details

Title:
Analysis of XFEL serial diffraction data from individual crystalline fibrils
Affiliation(s):
EuXFEL staff, Other
Author group:
Instrument SPB/SFX
Topic:
Scientific area:
Abstract:
Serial diffraction data collected at the Linac Coherent Light Source from crystalline amyloid fibrils delivered in a liquid jet show that the fibrils are well oriented in the jet. At low fibril concentrations, diffraction patterns are recorded from single fibrils; these patterns are weak and contain only a few reflections. Methods are developed for determining the orientation of patterns in reciprocal space and merging them in three dimensions. This allows the individual structure amplitudes to be calculated, thus overcoming the limitations of orientation and cylindrical averaging in conventional fibre diffraction analysis. The advantages of this technique should allow structural studies of fibrous systems in biology that are inaccessible using existing techniques.
Imprint:
2017
Journal Information:
International Union of Crystallography Journal, 4, 795–811 (2017)
Related external records:
Language(s):
English


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 Record created 2017-11-15, last modified 2018-12-19

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